Translational clinical imaging

Over the years, our group has spent a significant amount of time and effort developing state-of-the-art imaging techniques and systems. These portable systems and handheld probes aim to translate that technology in hopes of providing advanced optical diagnostic tools to clinicians. From the beginning of the build process, substantial consideration is given to the biological mechanisms of disease and how it can be better visualized with optical imaging. There are many constraints and requirements for operating in a clinical space that must also be addressed, including safety and ease of use factors at a minimum. 

Our group has had the privilege to work alongside talented physicians, nurses, clinical, and surgical staff at local hospitals, the UIUC Veterinary Hospital, and other partners. Many of the researchers in our group have research affiliate appointments at Carle Foundation Hospital, one of our major clinical sites in the Urbana-Champaign, IL area. After building these systems, our researchers transport and use these systems, often interacting directly with physicians and subjects in both outpatient settings and surgery (based on the project).

To prepare for these clinic-facing experiments, we often perform many experiments in-house on in vitro bacterial imaging, fresh ex-vivo samples, or small animal studies, which help refine the stability and ease of use of the system. To this end, we have installed a mock clinical exam room at the Beckman Institute and helps us to further refine these systems in-house. This room has the basic clinical capability (basic supplies, primary care tools, exam chair/bench) as well as a more advanced commercial retinal imaging system (Heidelberg Spectralis) and several of our own portable systems when not in use in-between experiments. Read on to learn more!